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A new study from Prof. Dr. Kader Karlı Oğuz ve Arzu Ceylan HAS has been published in Archives of Gerontology and Geriatrics. In the present study, the CSF Aβ1–42, t-tau, and p-tau181 levels as well-known biomarkers of Alzheimer Disease (AD) pathology as well as the CSF α-synuclein levels as another marker of synaptic and/or neuronal injury in a group of newly diagnosed patients with AD in comparison with the controls were analyzed. Default mode network (DMN) activity and cognitive profiles of the same subjects were also comparatively examined in relation to these biomarkers. As a novel finding, in DMN, decreased connectivity of the dorsal posterior cingulate cortex with the retrosplenial cortex was found to be closely related to decreased CSF Aβ1–42 levels in patients with AD.

Please see the following link for the full article:

doi:10.1016/j.archger.2015.09.010

 

 

Prof. Dr. Kader Karli Oguz and Arzu Ceylan HAS have a new publication that investigate the effects of smoking on regional brain volumes and lesion load in patients with clinically isolated syndrome by using quantitative magnetic resonance imaging. The study included age, sex and pack year matched 31 patients and 27 healthy controls, categorized in 4 groups as smoker patients and controls, nonsmoker patients and controls. Smoking duration was significantly negatively correlated with intracranial volume and left hemisphere cortical gray matter volume. Clinically Isolated Syndome related regional brain atrophy might vary in extent and severity with smoking. Despite increased lesion load, less cortical and deep gray matter damage with a possible neuroprotective effect occurs in smoking. Please see the following link for the full article: 

http://www.tandfonline.com/doi/full/10.3109/00207454.2015.1073727

A new study from Prof. Dr. Kader Karlı Oğuz ve Arzu Ceylan HAS has been published in International Journal of Neuroscience. Here, the differences in the white matter structure in the patients with Chronic relapsing inflammatory optic neuropathy (CRION) were studied. Fractional anisotropy, mean diffusivity, radial and axial diffusivity values were calculated in the identified region of interests. At the same time the average difference maps were obtained by TBSS in the patients with CRION. Please see the following link for the full article:

 http://dx.doi.org/10.3109/00207454.2014.896912

Two studies by Assoc.Prof. Oktay Algın have been published. Feasibility of 3D-SPACE sequence is investigated on the evaluation of patients with hydrocephalus in these studies. As a result, 3D-SPACE sequence is proven to be a right, fast and efficient method of diagnosing hydrocephalus. The sequence is also proved  to be efficient on  assessing the condition  after  treatment(shunt or ETV operations).

Feasibility of 3D-SPACE technique on the assessment of CSF was first shown by Dr. Algın 6 years ago on animal experiments. Studies about applications of this sequence  on various fields has been done since then in UMRAM. Please find more details in the links below:   

http://www.ncbi.nlm.nih.gov/pubmed/25978590
http://www.ncbi.nlm.nih.gov/pubmed/25859808

A recent paper by Asst. Prof. Emine Ulku Saritas has been published in Medical Physics. This work describes the dependence on duration of the human safety limits for time-varying magnetic fields. The results show for the first time that the nerve stimulation thresholds for magnetic fields decrease with increasing duration and that this effect is independent of frequency.The details of this study can be found at this link

Assistant Professors of UMRAM Tolga Cukur and Emine Ulku Saritas to be deemed to deserve TUBA GEBİP Award in 2015. This prestigious award is given to  the most promising young scientists of the year by The Turkish Academy of Sciences (TÜBA). They are  amongst the 38 scientists this year who has been awarded within the framework of The Young Scientists Award Programme.  The objective of TÜBA-GEBIP is to foster young, outstanding scientists  encourage them to  establish their own research programmes in Turkey. TUBA supports these scientists for a period of three years and helps them set up their own research groups at a stage when they are in need for incentives. 

Dr. Kafaligonul and his colleagues edited a special topic called “Feedforward and Feedback Processes in Vision”. The visual areas are interconnected through ascending feedforward projections, descending feedback projections, and projections from neural structures at the same hierarchical level. In order to provide recent views on the roles of feedforward and feedback projections in vision, around 35 vision scientists (from well-known institutes located in Europe and North America) contributed to this research topic. For a gist of the whole issue, the editorial article can be found at this link. The Ebook can be downloaded from here.