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An article by Dr. Hatice Pınar Gunbey of 19 Mayıs University and our researcher Arzu Ceylan Has has been published in European Radiology.  The researchers aim to provide an initial assessment of white matter (WM) integrity with diffusion tensor imaging (DTI) and the accompanying volumetric changes in WM and grey matter (GM) through volumetric analyses of young children withDown’s syndrome (DS).

Ten children with DS and eight healthy control subjects were included in the study. Tract-based spatial statistics(TBSS) were used in the DTI study for whole-brain voxel wise analysis of fractional anisotropy (FA) and mean diffusivity(MD) of WM. Volumetric analyses were performed with anautomated segmentation method to obtain regional measure-ments of cortical volumes.
The preliminary results suggest that DTI and volumetric analyses may reflect the earliest complementary changes of the neurodevelopmental delay in children with DS and can serve as surrogate biomarkers of the specific elements of WM and GM integrity for cognitive development. The full article can be found here: 

A research project of which imaging studies carried out in UMRAM has been published in Neuroscience Letters. The research entitled ‘Perisylvian GABA levels in schizophrenia and bipolar disorder' by Dr. Murat İlhan Atagün and his group has aimed  to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy (1H-MRS). In this study patients with schizophrenia (n = 25), bipolar I disorder (BD-I; n = 28) and bipolar II disorder (BD-II; n = 20) were compared with healthy controls (n = 30). 1H-MRS data was acquired using a Siemens 3 T whole body scanner to quantify right and left perisylvian structures’(including superior temporal lobes) GABAlevels. Right perisylvian GABAvalues differed significantly between groups [2 = 9.62, df: 3, p = 0.022]. It is concluded that GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p = 0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r2 = 0.68, p = 0.006, n = 33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The more on this article can be found here

 

 

A new study by UMRAM researchers Professor Kader Karlı Oguz and  Arzu Ceylan Has has been published in Multiple Sclerosis and Related Disorders's November issue. In this study,  the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline were investigated. For  this purpose thirty patients with clinically isolated syndrome and twenty demographically- matched healthy controls underwent neuropsychologic assessment through the Rao Brief Repeatable Battery, and brain magnetic resonance imaging with double inversion recovery using a 3T scanner.

In this study, It has been found that disease duration and educational years had contributions to some of the cognitive test scores, while age affected some volumetric measures of the brain. So while analyzing the correlations between test performances and volumetric measures, our researchers has controlled these confounding factors. By doing so, the accuracy of the correlations has also been controlled. In our patients with CIS, it was shown that cognitive impairment was mainly related to cerebral white matter, cerebellar cortical and deep gray matter atrophy, but not with cortical inflammation, at least in the early stage of disease. For article please go:

 

This year we have celebrated new year early by combining it with the Aysel Sabuncu Brain Research Center 2016 Scientific Meeting. The day started with Dr. Emre Guven's excellent talk on compressed sensing. Short four talks from the researcher of our center followed an enlightening talk by Prof. Turgay Dalkara on discovering brain. Attendance exceed the capacity of our conference room. Later 38 posters were presented and dinner was served. The event lasted about 6 hours and the total attendance was over 100 people. UMRAM and Aysel Sabuncu Brain Research Center would like to thank all speakers, and poster presenters and well as guests of the event.

 

 

A new study by UMRAM researchers has been published in Nature Scientific Reports. Using a rapid motion adaptation paradigm, they investigated the dynamics of spatiotemporal correlation between ON and OFF pathways in human vision. Their results indicated distinct temporal dynamics for the spatiotemporal correlation within and across pathway mechanisms. Click here for further information and the journal article. 

Redi Poni defended his MS thesis on Aug 15, 2016. His thesis title was "A Digitally Controlled Class-E Amplifier for MRI". In the thesis, Redi showed the feasibility of using a class-E amplifier as a very efficient amplifier for transmission of RF signal.  Furthermore, he showed that these amplifiers can be controlled digitally. The top panel of the figure shows phantom images obtained using two of these amplifiers working simultaneously. The bottom panel shows the MR image obtained when only one channel is used. Redi will continue his PhD studies in France.

Salman Ul Hassan Dar defended his thesis on Aug 2, 2016. His thesis title was 'Inter-regional connectivity in the human brain during visual search'. The focus of this work was on the inter-regional functional and effective connectivity in the human brain during natural visual search tasks.  His thesis defense committee was composed of Dr. Fatoş Yarman Vural (Middle East Technical University), Dr. Emine Ülkü Sarıtaş (Bilkent University) and Dr. Tolga Çukur (Bilkent University). His thesis adviser was Dr. Tolga Çukur. Salman will continue as a PhD student with Dr. Tolga Çukur.