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An article by Dr. Hatice Pınar Gunbey of 19 Mayıs University and our researcher Arzu Ceylan Has has been published in European Radiology.  The researchers aim to provide an initial assessment of white matter (WM) integrity with diffusion tensor imaging (DTI) and the accompanying volumetric changes in WM and grey matter (GM) through volumetric analyses of young children withDown’s syndrome (DS).

Ten children with DS and eight healthy control subjects were included in the study. Tract-based spatial statistics(TBSS) were used in the DTI study for whole-brain voxel wise analysis of fractional anisotropy (FA) and mean diffusivity(MD) of WM. Volumetric analyses were performed with anautomated segmentation method to obtain regional measure-ments of cortical volumes.
The preliminary results suggest that DTI and volumetric analyses may reflect the earliest complementary changes of the neurodevelopmental delay in children with DS and can serve as surrogate biomarkers of the specific elements of WM and GM integrity for cognitive development. The full article can be found here: