European patent application (WO2015167408)(PCT/TR2014/000248) entitled "NANOPARTICLE FORMULATION CONTAINING FARNESYLTHIOSALICYCLIC ACID" has been concluded positively and the registration decision has been finalized. Farnesylthiosalicylic acid (Salirasib, FT A), a new generation antineoplastic agent, is a specific inhibitor of Ras protein, which presents in high rate in most of malignant tumors.The patentable study is a targeted chemotherapy  to change the disposition, uptake or efficacy of antineoplastic drugs by providing more damages to tumor cells rather than normal cells. Former UMRAM researcher Taner Demir and UMRAM  Professor Kader Karlı Oguz are among the invention owners.  Other  authors  includes  Sibel PEHLİVAN, İmran VURAL, Melike Mut AŞKUN, Figen SÖYLEMEZOĞLU of Hacettepe University Medical School and Abbas KAFFASHI, Sevda LÜLE, Hüsnü KOŞUCU, Can SARISÖZEN.  See: 

Utku Kaya (Graduate Researcher at UMRAM) successfully defended his PhD thesis entitled “Neural Mechanisms Underlying Sub-second Crossmodal Time Perception”. He aimed to understand neural correlates of auditory influences on perceived visual timing, visual time intervals and apparent motion. To achieve this aim, he designed precise experiments within sub-second range and provided comprehensive EEG analyses.

We would like to congratulate Fatima Tu Zahra for receiving the master of science degree from Bilkent EEE. Her thesis title is "Highly Efficient 300 W Modified Class-E RF Amplifiers for 64 MHz Transmit Array System". She managed her 2x300W amplifiers work in MRI scanner as in TxArray mode. Her supervisor was Ergin Atalar. She is planning to return back to Pakistan. Her husband Nasir will be joining her in the early summer of 2018. 

UMRAM researchers have recently published a journal article in Experimental Brain Research. In their study, they focused on brain mechanisms and principles coordinating crossmodal and intramodal perceptual grouping. By designing different experiments on perceived speed, they found that certain spatial grouping principles of vision can take precedence over audiovisual interactions in time. Moreover, their findings indicated that the effects of sound timing on perceived speed exist in different spatial configurations. These behavioral findings have implications for designing systems that take the multisensory nature of motion perception and speed estimation into account. Click here for further information and the journal article.

UMRAM researchers has recently published an article titled as “A z-gradient array for simultaneous multi-slice excitation with a single band RF pulse”. It is shown that multiple slices can be excited with a single band RF pulse using a custom designed z-gradient array. In recent years, imaging multiple slices at the same time, multi-slice MRI, has become popular due to reduced imaging time or increased SNR. In the conventional techniques, excitation of multiple slices cause increase in the peak voltage, peak power, specific absorption rate (SAR). Therefore, design of multi-slice RF pulses are limited by RF power amplifier limitations or safety limits related to SAR. In this study, a z-gradient array is used to create spatially oscillating magnetic fields such that multiple locations can be excited with a conventional single band RF pulse; therefore, increase in the peak power, peak voltage, SAR or RF pulse durations can be avoided. Novel z-gradient hardware including 9 channel z-gradient array, Tx/Rx RF coils, 9 power amplifiers and control circuits are introduced. Design techniques and performance evaluations for various target specifications are also analyzed. At last, MR experiments has been conducted to validate the proposed technique and multiple slices are successfully excited with a single band RF pulse using the z-gradient array coil.

In a recent publication from UMRAM researchers, it is shown that simultaneous use of linear and nonlinear gradients provides better B1+ inhomogeneity correction than using only linear or only nonlinear gradients. In high field scanners (3T or above), perfectly spatially homogeneous radio frequency (RF) pulse cannot be achieved inside the body because wavelength becomes comparable with the object dimension. In literature, spoke excitation, which uses RF pulses together with the commercial linear gradient fields, can provide more homogeneous excitation by correcting the B1+ inhomogeneity. In this study, it is shown that when there are additional nonlinear gradient fields driven by independent amplifiers, degree of freedom in the excitations problem is increased. Formulations and design techniques are formulated in the study. In an example experiment, transmit inhomogeneity is decreased 46% while it can only be decreased 20% with the original hardware of the scanner in the same scenario. 

UMRAM researchers published a novel work in MRM journal in collaborating with UNAM team. This study presents an inductively coupled ultra-thin, flexible, and passive RF resonator for MRI marking and guiding purposes with clinical feasibility. Standard microfabrication processing was used to fabricate the resonant marker.
The proposed marker consists of two metal traces in the shape of a square with an edge length of 8 mm, with upper and lower traces connected to each other by a metalized via. A 3T MRI fiducial marking procedure was tested in phantom and ex vivo, and then the marker's performance was evaluated in an MRI experiment using humans. The ultra-thin and flexible structure of this wireless flexible RF resonant marker offers effective and safe MR visualization with high feasibility for anatomic marking and guiding in various regions of the body.

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